SARS-CoV-2 main protease inhibitors: What is moving in the field of peptides and peptidomimetics?Article Published on 2023-05-012023-07-11 Journal: Journal of peptide science : an official publication of the European [Category] COVID19(2023년), [키워드] covalent COVID-19 inhibitors main protease MPro peptides peptidomimetics. SARS-CoV-2 [DOI] 10.1002/psc.3467 PMC 바로가기
The progress of molecules and strategies for the treatment of HBV infectionReview Published on 2023-03-152023-06-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] B형 간염, [키워드] HBV HBV life cycle inhibitors molecules Treatment. [DOI] 10.3389/fcimb.2023.1128807 PMC 바로가기 [Article Type] Review
Overview of the development of HBV small molecule inhibitorsReview Published on 2023-03-052023-06-11 Journal: European journal of medicinal chemistry [Category] B형 간염, [키워드] cccDNA drug design HBV inhibitors virus. [DOI] 10.1016/j.ejmech.2023.115128 PMC 바로가기 [Article Type] Review
An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
Exploring Highly Conserved Regions of SARS-CoV-2 Spike S2 Subunit as Targets for Fusion Inhibition Using Chimeric ProteinsArticle Published on 2022-12-072023-07-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] antivirals calorimetry coronavirus COVID-19 inhibitors Protein design protein engineering. [DOI] 10.3390/ijms232415511 PMC 바로가기
Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain원숭이와 생쥐의 비교 miRNA 전사체는 MYOC가 뇌로의 크립토코커스 네오포르만스 침입에 대한 억제제임을 보여줍니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] 유전자 메커니즘, [키워드] AIDS Brain brain dissemination brains C. neoforman C. neoformans caused Central nervous system centric clinical samples clinically CNS Comparative Cryptococcal meningoencephalitis cryptococcosis Cryptococcus neoforman Cryptococcus neoformans cytoskeleton dissemination enhancer facilitate fungal Fungal infection help HIV/AIDS HIV/AIDS patient HIV/AIDS patients host-pathogen interactions hosts human pathogen Immune cell immune cells individuals Infection inhibitor inhibitors Invasion macaque Macrophage mechanism meningoencephalitis mice miRNA miRNA transcriptome. MYOC myocilin Pathogenic microorganisms pathway Patient patients with COVID-19 performed Prevalence regulated response reveal Transcriptome transcriptomics Trojan horse [DOI] 10.1080/22221751.2022.2081619 PMC 바로가기 [Article Type] Article
Acriflavine and proflavine hemisulfate as potential antivirals by targeting MproArticle Published on 2022-12-012022-11-15 Journal: Bioorganic chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] ACF acriflavine activity addition anti-SARS-CoV-2 Antiviral antiviral target BHK-21 cell Compound Coronaviruses demonstrated effective drugs effort enzymatic assay experiment HCoV-OC43 in vitro Infection inhibited inhibitor inhibitors inhibitory activity M pro M(pro) inhibitor MPro Proflavine Proflavine hemisulfate Remdesivir Replication reported SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 virus SARS-CoV-2. Transcription Viral RNA [DOI] 10.1016/j.bioorg.2022.106185 PMC 바로가기
SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including OmicronSARS-CoV-2 융합 억제 리포펩티드는 오미크론을 포함한 다양한 관심 변종에 대해 높은 효능을 유지합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity Alpha antiviral activity Beta broad-spectrum antiviral broad-spectrum antivirals Cell Cell fusion cell-cell fusion combating COVID-19 pandemic D614G Delta drugs effective vaccine Effective vaccines exhibited FIVE fusion inhibitor Gamma Impact Infection inhibiting inhibitor inhibitors Lambda lipopeptide maintain mutant omicron Omicron variant other variant other variants outbreak pseudovirus pseudovirus pseudovirus infection pseudoviruses reduced S protein S proteins SARS-CoV-2 significantly the S protein therapeutic variant variants variants of concern variants of concern. VoC VOCs wild-type WT virus [DOI] 10.1080/22221751.2022.2098060 PMC 바로가기 [Article Type] Article
Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS-CoV-2 Infection and COVID-19Review Published on 2022-11-182023-07-10 Journal: ChemMedChem [Category] COVID19(2023년), [키워드] antiviral drugs coronavirus COVID-19 drug design inhibitors protein X-ray structures. SARS-CoV-2 [DOI] 10.1002/cmdc.202200440 PMC 바로가기 [Article Type] Review
Practical considerations to establish a validated platform for pooled detection of SARS-CoV-2 by droplet digital PCRArticle Published on 2022-11-042022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] addition affected amplification analyzed approach Blood carried COVID-19 pandemic Critical Ct value detect detection diagnostic diagnostic capabilities digital PCR Dilution droplet False negative Health hospital Infectious disease inhibitors invasive Laboratory less limitation Nasopharyngeal samples parameter PCR platform pool positive sample reagent reagents reduce reducing resources resulting risk Saliva SARS-CoV-2 sensitivity the SARS-CoV-2 virus load was performed [DOI] 10.1371/journal.pone.0271860 PMC 바로가기